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Amongst 461 patients with an elevated dTT or ECT at baseline, the median maximum percentage reversal was 100%. The full cohort analysis included 503 patients (301 with serious bleeding and 202 requiring an urgent procedure). TEG ®: ↑ R time, K time, α angle, MRTG (kaolin test) ↑ ACT, unchanged K time, α angle and MRTG (rTEG test) ROTEM™: ↑ EXTEM CT, ↑ or unchanged INTEM CT ↑ or unchanged (limited sensitivity, may vary with reagent) Modified ROTEM™: ↑ CT and t,MaxVel (lowTF–ROTEM™), with wide variability ROTEM™: ↑ or unchanged EXTEM CT and INTEM CT TEG ®: ↑ R, K, α angle, and MRTG (kaolin test) only at higher levels ↑ ACT with dose-response correlation, K, unchanged α angle and MRTG (rTEG test) ↑ or unchanged (not sensitive at low levels, varies with reagent) ROTEM™: ↑ CT (INTEM and EXTEM), ↑ or unchanged CFT, no effect on MCF TEG ®: ↑ R, K, and MRTG with dose response correlation, ↑ or unchanged α angle and MA (kaolin test) ↑ ACT with dose-response correlation, ↑ or unchanged K, α angle and MRTG (rTEG test)

↑ or unchanged (low sensitivity, varies with reagent) Point-of-care viscoelastic tests (TEG ®/ROTEM™) aPTT, activated partial thromboplastin time CFT, clot formation time CT, clotting time dTT, dilute thrombin time ECT, ecarin clotting time K, coagulation time lowTF–ROTEM ®, low–tissue factor activated ROTEM ® MA, maximum amplitude MCF, maximum clot firmness MRTG, maximum rate of thrombus generation PT, prothrombin time R, reaction time t,MaxVel, time to maximum velocity TT, thrombin time

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